Activator 2 Protein May Play Role in Tumor Proliferation.(Statistical Data Included)(Brief Article)

2000 JUN 13 - (NewsRx.com) --

Prostate tumors that are low in activator protein 2 (AP-2) tend to lack differentiation.

AP-2, a transcription factor, stimulates p21 (waf1/cip1) expression, which inhibits cell growth by blocking the action of cyclin-dependent kinases that play a role in G1-S progression. P. Lipponen and colleagues at the University of Kuopio, Finland, looked for associations between AP-2 expression and other aspects of prostate cancer, including mortality.

The researchers employed immunohistochemistry to investigate AP-2 (alpha) expression in 215 prostate cancers. They compared these data with other information gathered from the …